Total synthesis of (-)-okilactomycin.
نویسندگان
چکیده
A highly convergent synthesis of (-)-okilactomycin is described. Key reactions of this synthesis include a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis-Ferrier union/rearrangement tactic, and an efficient RCM reaction to construct the 13-membered macrocyclic ring.
منابع مشابه
Okilactomycin, a novel antibiotic produced by a Streptomyces species. II. Structure determination.
Structure of a novel antibiotic, okilactomycin, was determined by a combination of spectroscopic and X-ray crystallographic studies. Okilactomycin has a unique structure containing 13-membered ring cyclized by carbon-carbon bond.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 129 48 شماره
صفحات -
تاریخ انتشار 2007